- Saarinen, Eero
- Saarinen, Eliel
- Sackville-West, Vita
- Safdie, Moshe
- Saint Laurent, Yves
- Saint-Gaudens, Augustus
- Salieri, Antonio
- Salinas de Gortari, Carlos
- Salle, David
- Salonen, Esa-Pekka
- Samaras, Lucas
- Samuel Pepys
- Sandburg, Carl
- Sander, August
- Santayana, George
- Saramago, Jose
- Sarazen, Gene
- Saroyan, William
- Sartre, Jean-Paul
- Savimbi, Jonas
- Scalia, Antonin
- Schiaparelli, Elsa
- Schiele, Egon
- Schliemann, Heinrich
- Schmidt, Helmut
- Schnabel, Artur
- Schnitzler, Arthur
- Schoenberg, Arnold
- Schopenhauer, Arthur
- Schulberg, Budd
- Schulz, Bruno
- Schurz, Carl
- Schwartz, Delmore
- Schweitzer, Albert
- Schwitters, Kurt
- Scott, Thomas
- Segal, George
- Seko, Mobutu Sese
- Selassie, Haile
- Sen, Hun
- Serkin, Rudolf
- Serra, Richard
- Sessions, Roger
- Seurat, Georges
- Sexton, Anne
- Shaffer, Peter
- Shahn, Ben
- Shakespeare, William
- Shamir, Yitzhak
- Sharon, Ariel
- Sheeler, Charles
- Sherman, Cindy
- Sherman, John
- Shoemaker, Bill
- Shostakovich, Dmitri
- Shui-Bian, Chen
- Signac, Paul
- Signorelli, Luca
- Sills, Beverly
- Simenon, Georges
- Simitis, Costas
- Simon, Neil
- Simpson, Louis
- Sinclair, Upton
- Singh, Manmohan
- Siskind, Aaron
- Sisley, Alfred
- Slatkin, Leonard
- Sloan, John
- Smith, Bessie
- Smith, Iain Duncan
- Smith, James
- Smith, John
- Smith, Joseph
- Smith, Red
- Smith, Robert
- Smith, Tony
- Smith, Venture
- Smith, William
- Smithson, Robert
- Snead, Sam
- Snow, Bob
- Snow, Tony
- Snyder, Gary
- Sontag, Susan
- Soros, George
- Sowerby, Leo
- Soyinka, Wole
- Spassky, Boris
- Speck, Richard
- Squanto
- Steffens, Lincoln
- Stegner, Wallace
- Steichen, Edward
- Stein, Gertrude
- Steinbeck, John
- Steinberg, Saul
- Steinem, Gloria
- Steiner, Rudolf
- Stella, Frank
- Stella, Joseph
- Stern, Isaac
- Sterne, Laurence
- Stevens, Thaddeus
- Stevens, Wallace
- Stevenson, Adlai
- Stewart, Charles
- Stewart, Jackie
- Stewart, Payne
- Stickley, Gustav
- Stieglitz, Alfred
- Stockhausen, Karlheinz
- Stockton, Richard
- Stoker, Bram
- Stokowski, Leopold
- Stone, Robert
- Stoppard, Tom
- Stout, Rex
- Stowe, Harriet Beecher
- Strachey, Lytton
- Strand, Mark
- Strand, Paul
- Strasberg, Lee
- Strauss, Leo
- Strauss, Richard
- Strayhorn, Billy
- Stroessner, Alfredo
- Stuart, Gilbert
- Sturges, Preston
- Stuyvesant, Peter
- Sukarnoputri, Megawati
- Sumner, Charles
- Sunday, Billy
- Swift, Jonathan
- Szell, George
- Szilard, Leo
- Szymanowski, Karol